Biosynthetic polyphosphate enhances osteogenesis of human periodontal ligament stem cells and promotes periodontal bone regeneration in a murine periodontal bone defect model

IntroductionPeriodontal bone regeneration remains a significant challenge in clinical dentistry due to the complex structure of periodontal tissues and their limited intrinsic regenerative capacity. Innovative biomaterial-based strategies are therefore required. Polyphosphates (Poly(P)) have shown p...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Jiaqi Chen, Dongying Lei, Xinyi Liu, Zipeng Chen, Jiaying Li, Liang Huang, Huifen Liu, Xuebin Yang, Wei Wei, Sijing Xie
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	polyphosphates hPDLSCs osteogenic differentiation periodontal bone regeneration tissue regeneration
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1672295/full