Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen

Ketoprofen is an anti-inflammatory agent that may cause gastric irritation if administered orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue. However, ketoprofen has a low solubility; therefore, it is essential to enhance its solubility using certain methods, n...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Delly Ramadon, Fathin Ulayya, Annisa Sakinah Qur’ani, Iskandarsyah Iskandarsyah, Yahdiana Harahap, Qonita Kurnia Anjani, Vania Aileen, Pietradewi Hartrianti, Ryan F. Donnelly
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	co-grinding dissolving microneedles ketoprofen nanosuspension solubility
Online Access:	https://www.mdpi.com/1424-8247/16/3/378