Amplification of the CXCR3/CXCL9 axis via intratumoral electroporation of plasmid CXCL9 synergizes with plasmid IL-12 therapy to elicit robust anti-tumor immunity

Clinical studies have demonstrated that local expression of the cytokine IL-12 drives interferon-gamma expression and recruits T cells to the tumor microenvironment, ultimately yielding durable systemic T cell responses. Interrogation of longitudinal biomarker data from our late-stage melanoma trial...

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Bibliographic Details

Published in:	Molecular Therapy: Oncolytics
Main Authors:	Jack Y. Lee, Bianca Nguyen, Anandaroop Mukhopadhyay, Mia Han, Jun Zhang, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Erica Browning, H. Kim Lyerly, David A. Canton, Daniel Fisher, Adil Daud, Alain Algazi, Joseph Skitzki, Christopher G. Twitty
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Subjects:	IL-12 tavokinogene telseplasmid electroporation CXCL9 CXCR3 chemotaxis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2372770522000572