Tocilizumab Contributes to the Inflammatory Status of Mature Dendritic Cells through Interleukin-6 Receptor Subunits Modulation

Tocilizumab, a humanized anti-IL-6 receptor α (IL-6Rα) is widely used in the treatment of a panel of pathologies such as adult and juvenile rheumatoid arthritis (RA) and the systemic form of juvenile idiopathic arthritis in children. Its indications are expected to be largely extended to other infla...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Daniel Meley, Audrey Héraud, Valerie Gouilleux-Gruart, Fabrice Ivanes, Florence Velge-Roussel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Subjects:	dendritic cell tocilizumab IL-6 receptor subunits rheumatoid arthritis inflammation
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00926/full