Effectiveness of anti-erythropoietin producing Hepatocellular receptor Type-A2 antibody in pancreatic cancer treatment

Erythropoietin-producing hepatocyte receptor type A2 (EphA2) is a tyrosine kinase that binds to ephrins (e.g., ephrin-A1) to initiate bidirectional signaling between cells. The binding of EphA2 and ephrin-A1 leads to the inhibition of Ras-MAPK activity and tumor growth. During tumorigenesis, the nor...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Fu-Ling Chang, Keng-Chang Tsai, Tsai-Yu Lin, Chen-Wei Chiang, Shiow-Lin Pan, Yu-Ching Lee
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	Erythropoietin-producing hepatocyte receptor type-A2 Pancreatic cancer Phage display EphA2 degradation Improved effects
Online Access:	http://www.sciencedirect.com/science/article/pii/S240584402308982X