Dose Finding in Oncology Trials Guided by Ordinal Toxicity Grades Using Continuous Dose Levels

We present a Bayesian adaptive design for dose finding in oncology trials with application to a first-in-human trial. The design is based on the escalation with overdose control principle and uses an intermediate grade 2 toxicity in addition to the traditional binary indicator of dose-limiting toxic...

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Bibliographic Details

Published in:	Entropy
Main Authors:	Mourad Tighiouart, André Rogatko
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Subjects:	cancer phase I trials maximum tolerated dose ordinal toxicity grade proportional odds model overdose control continuous dose
Online Access:	https://www.mdpi.com/1099-4300/26/8/687