Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue

Abstract Background Abdominal obesity is appreciated as a major player in insulin resistance and metabolically dysfunctional adipose tissue. Inappropriate extracellular matrix (ECM) remodelling and functional alterations in human adipose stromal/stem cells (hASCs) have been linked with visceral whit...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Xueya Han, Weihong Li, Xu He, Xin Lu, Yu Zhang, Yaqiong Li, Guoyun Bi, Xuqing Ma, Xiaowu Huang, Rixing Bai, Haiyan Zhang
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	Human adipose stromal/stem cell Obesity, visceral white adipose tissue Cell-derived extracellular matrix Mitochondria TGF-β1 Ageing
Online Access:	https://doi.org/10.1186/s13287-023-03525-y