Quantitative Explanation of Retention Mechanisms of Hydrophobic and Hydrophilic-Interaction Liquid Chromatography-Inductive Effect of Alkyl Chain

The basic retention mechanisms of reversed-phase and hydrophilic-interaction liquid chromatography (HILIC) were quantitatively analyzed using simple molecular mechanics (MM) calculations. The model bonded phases were composed of an alkyl chain bonded to siloxane-like molecules. The head of the alkyl...

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Bibliographic Details

Published in:	Separations
Main Author:	Toshihiko Hanai
Format:	Article
Language:	English
Published:	MDPI AG 2017-11-01
Subjects:	retention mechanism hydrophobic interaction hydrophilic interaction inductive effect of alkyl chain computational chemistry
Online Access:	https://www.mdpi.com/2297-8739/4/4/33