Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the ca...

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Bibliographic Details

Published in:	Genes and Diseases
Main Authors:	Kevin Qin, Michael Yu, Jiaming Fan, Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2024-01-01
Subjects:	β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304223000557