Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage

Increasing evidence shows that metabolic factors are involved in the pathological process of osteoarthritis (OA). Lactate has been shown to contribute to the onset and progression of diseases. While whether lactate is involved in the pathogenesis of OA through impaired chondrocyte function and its m...

詳細記述

書誌詳細

出版年:	Redox Biology
主要な著者:	Yi-Fan Huang, Guan Wang, Lu Ding, Zi-Ran Bai, Yi Leng, Jun-Wei Tian, Jian-Zeng Zhang, Yan-Qi Li, Ahmad, Yuan-Hua Qin, Xia Li, Xin Qi
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2023-11-01
主題:	Lactate Osteoarthritis Chondrocytes NADPH oxidase 4
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2213231723002689