Recycling machinery of integrin coupled with focal adhesion turnover via RAB11-UNC13D-FAK axis for migration of pancreatic cancer cells

Abstract Background Recycling of integrin via endosomal vesicles is critical for the migration of cancer cells, which leads to the metastasis of pancreatic cancer and devastating cancer-related death. So, new diagnostic and therapeutic molecules which target the recycling of endosomal vesicles need...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Van-Thanh Duong, Mihyang Ha, Jayoung Kim, Ji-Young Kim, Siyoung Park, Khatun Mst Reshma, Myoung-Eun Han, Dongjun Lee, Yun Hak Kim, Sae-Ock Oh
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	UNC13D RAB11 FAK Integrin Focal adhesion Migration
Online Access:	https://doi.org/10.1186/s12967-024-05630-9