Increased METTL3-mediated m6A methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure

Abstract Background Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N6-methyladenosine (m6A) has been demonstrated to be involved in various biological processes, its potential role in...

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Bibliographic Details

Published in:	Reproductive Biology and Endocrinology
Main Authors:	Pingping Xue, Wenbo Zhou, Wenqiang Fan, Jianya Jiang, Chengcai Kong, Wei Zhou, Jianmei Zhou, Xiaoyang Huang, Haiyan Yang, Qian Han, Bin Zhang, Lingyun Xu, Bin Yu, Li Chen
Format:	Article
Language:	English
Published:	BMC 2021-12-01
Subjects:	METTL3 m6A methylation HOXA10 embryo implantation recurrent implantation failure
Online Access:	https://doi.org/10.1186/s12958-021-00872-4