DESI-TQ-MS imaging for ex vivo brain biodistribution assessment: evaluation of LBT-999, a ligand of the dopamine transporter (DAT)

Abstract Background Selection of the most promising radiotracer candidates for radiolabeling is a difficult step in the development of radiotracer pharmaceuticals, especially for the brain. Mass spectrometry (MS) is an alternative to study ex vivo the characteristics of candidates, but most MS studi...

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Bibliographic Details

Published in:	EJNMMI Radiopharmacy and Chemistry
Main Authors:	Laurent Galineau, Emmanuelle Claude, Zuhal Gulhan, Sylvie Bodard, Sophie Sérrière, Camille Dupuy, Jérémy Monteiro, Adeline Oury, Priscila Bertevello, Gabrielle Chicheri, Johnny Vercouillie, Lydie Nadal-Desbarats, Sylvie Chalon, Antoine Lefèvre, Patrick Emond
Format:	Article
Language:	English
Published:	SpringerOpen 2024-08-01
Subjects:	Radiotracer development Mass spectrometry Desorption electrospray ionization Triple quadrupole type analyzer LBT-999
Online Access:	https://doi.org/10.1186/s41181-024-00289-5