Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

To progress towards differentiation, progeny of stem cells need to extinguish expression of stem-cell maintenance genes. Failures in such mechanisms can drive tumorigenesis. In Drosophila neural stem cell (NSC) lineages, excessive Notch signalling results in supernumerary NSCs causing hyperplasia. H...

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Bibliographic Details
Published in:eLife
Main Authors: Evanthia Zacharioudaki, Julia Falo Sanjuan, Sarah Bray
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Subjects:
Notch
stem cells
NuRD Complex
Online Access:https://elifesciences.org/articles/41637

Internet

https://elifesciences.org/articles/41637

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