The p53 tumor suppressor regulates AKR1B1 expression, a metastasis-promoting gene in breast cancer

Alteration of metabolism in cancer cells is a central aspect of the mechanisms that sustain aggressive traits. Aldo–keto reductase 1 B1 (AKR1B1) catalyzes the reduction of several aldehydes to alcohols consuming NADPH. Nevertheless, the ability of AKR1B1 to reduce different substrates renders diffic...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Carolina Di Benedetto, Carla Borini Etichetti, Nabila Cocordano, Alejo Cantoia, Evelyn Arel Zalazar, Silvio Bicciato, Mauricio Menacho-Márquez, Germán Leandro Rosano, Javier Girardini
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Subjects:	aldo–keto reductase 1 B1 p53 metastasis breast cancer aldo–keto reductases electron transport chain
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1145279/full