PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT

Glioblastoma multiforme (GBM) is the most malignant brain tumor and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies and complex biology. Among the numerous pathways driving GBM biology studied so far, PTEN/phosphatidylinositol-4,5-bisphosphate 3-kinase...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Carmen Mecca, Ileana Giambanco, Stefano Bruscoli, Oxana Bereshchenko, Bernard Fioretti, Carlo Riccardi, Rosario Donato, Cataldo Arcuri
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-04-01
Subjects:	glioblastoma mTOR mTORC2 rapamycin PP242
Online Access:	http://journal.frontiersin.org/article/10.3389/fncel.2018.00099/full