NAT10-mediated ac4C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis

Abstract Background Sepsis-induced pulmonary injury (SPI) is a common complication of sepsis with a high rate of mortality. N4-acetylcytidine (ac4C) is mediated by the ac4C “writer”, N-acetyltransferase (NAT)10, to regulate the stabilization of mRNA. This study aimed to investigate the role of NAT10...

Full description

Bibliographic Details

Published in:	Molecular Medicine
Main Authors:	Pengcheng Xing, Minjie Zhou, Jian Sun, Donglian Wang, Weipeng Huang, Peng An
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Sepsis-induced pulmonary injury NAT10 Ac4C TFRC Ferroptosis
Online Access:	https://doi.org/10.1186/s10020-024-00912-w