Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles

Background: Lactate dehydrogenase (LDH) is one of the important enzyme systems for glycolysis and gluconeogenesis. It can catalyze the reduction and oxidation reaction between propionic acid and L-lactic acid, which is usually overexpressed in cancer cells. Therefore, inhibiting the activity of LDH...

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Bibliographic Details

Published in:	Frontiers in Bioscience-Landmark
Main Authors:	Feng Zhang, Huiyun Li, Chao Liu, Kun Fang, Yongmei Jiang, Mingjiang Wu, Shiji Xiao, Lei Zhu, Jiaqi Yu, Shenge Li, Gang Wang
Format:	Article
Language:	English
Published:	IMR Press 2022-07-01
Subjects:	lactate dehydrogenase (ldh) inhibitor functionalized magnetic nanoparticles selaginella doederleini biflavonoids ligand fishing
Online Access:	https://www.imrpress.com/journal/FBL/27/8/10.31083/j.fbl2708229