Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes

Abstract Background Colorectal cancer (CRC) presents significant treatment challenges due to its high heterogeneity and complex intercellular interactions. Further exploration of CRC subtypes and interactions among tumor-specific clusters will facilitate the development of personalized treatment str...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Youpeng Wang, Xingfeng Qiu, Qinghai Li, Jiale Qin, Lvlan Ye, Xiang Zhang, Xingxiang Huang, Xiangqiong Wen, Ziyang Wang, Weiling He, Yuqin Di, Qi Zhou
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Colorectal cancer Single-cell RNA sequencing Cancer-associated fibroblast (CAF) Chemoresistance
Online Access:	https://doi.org/10.1186/s12967-025-06103-3