Comprehensive genomic profiling of Chinese lung cancer characterizes germline-somatic mutation interactions influencing cancer risk

Abstract Background Germline mutations in numerous genes, particularly tumor suppressor genes, markedly heighten the risk of various cancers, including lung cancer, which is the leading cause of cancer-related deaths worldwide. Despite extensive research on well-known genes like BRCA1, BRCA2, and mi...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Ning Zhou, Yuanyuan Xu, Yumin Huang, Guoxiang Ye, Liang Luo, Zuodong Song
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Germline mutation Somatic mutation Genetic susceptibility Lung cancer Cancer risk
Online Access:	https://doi.org/10.1186/s12967-025-06096-z