Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage

Abstract Intracerebral hemorrhage (ICH) is a lethal and highly morbid form of stroke for which there is no disease-specific therapy. Inflammation after ICH is an important mechanism of secondary damage, and the inflamed endothelium in ICH is a promising therapeutic target as it is the gateway for re...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Sahily Reyes-Esteves, Aparajeeta Majumder, Nicolas Marzolini, Marco E. Zamora, Soomin Jeong, Yufei Wang, Manthan N. Patel, Carolann Espy, Tyler Ellis Papp, Awurama Akyianu, Jia Nong, Lawson Messe, Serena Omo-Lamai, Hamideh Parhiz, Jacob W. Myerson, Oscar A. Marcos-Contreras, Jacob S. Brenner
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Intracerebral hemorrhage Endothelial inflammation Targeted nanoparticles Brain drug delivery Hemorrhagic stroke
Online Access:	https://doi.org/10.1186/s12974-025-03541-0