IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling.
The tumor suppressor IKAROS binds and represses multiple NOTCH target genes. For their induction upon NOTCH signaling, IKAROS is removed and replaced by NOTCH Intracellular Domain (NICD)-associated proteins. However, IKAROS remains associated to other NOTCH activated genes upon signaling and inducti...
| 出版年: | PLoS Genetics |
|---|---|
| 主要な著者: | , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Public Library of Science (PLoS)
2021-03-01
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| オンライン･アクセス: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009478&type=printable |