Cell Cycle-Associated CXCR4 Expression in Germinal Center B Cells and Its Implications on Affinity Maturation

Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Wit...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Author:	Tom S. Weber
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-06-01
Subjects:	germinal center cell cycle BrdU CXCR4 CXCL12 dark zone
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01313/full