Cell Cycle-Associated CXCR4 Expression in Germinal Center B Cells and Its Implications on Affinity Maturation

Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Wit...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Author:	Tom S. Weber
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-06-01
Subjects:	germinal center cell cycle BrdU CXCR4 CXCL12 dark zone
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01313/full

Similar Items

Multiplex Cell Fate Tracking by Flow Cytometry
by: Marta Rodríguez-Martínez, et al.
Published: (2020-07-01)

Neurogenesis induced by seizures in the dentate gyrus is not related to mossy fiber sprouting but is age dependent in developing rats A neurogênese induzida por crises no giro denteado não está relacionada ao brotamento de fibras musgosas, mas é dependente da idade, em ratos durante o desenvolvimento
by: Yaima del Carmen Garrido Sanabria, et al.
Published: (2008-12-01)

Effectivity of Two Cell Proliferation Markers in Brain of a Songbird Zebra Finch
by: Lubica Kubikova, et al.
Published: (2020-10-01)

IS4‐FAM, a fluorescent tool to study CXCR4 affinity and competitive antagonism in native cancer cells
by: Isabel Hamshaw, et al.
Published: (2024-10-01)

Neuronal regeneration in the goldfish telencephalon following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) insult
by: Maddie J. Venables, et al.
Published: (2018-03-01)

Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells
by: Heinrich Eileen L, et al.
Published: (2012-04-01)

Differential alterations in the small intestine epithelial cell turnover during acute and chronic infection with Echinostoma caproni (Trematoda)
by: Alba Cortés, et al.
Published: (2015-06-01)

Birthdate study of GABAergic neurons in the lumbar spinal cord of the glutamic acid decarboxylase 67-green fluorescent protein knock-in mouse
by: Jing eHuang, et al.
Published: (2013-12-01)

The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases
by: Rojin Sarallah, et al.
Published: (2025-02-01)

Electroconvulsive seizures regulate various stages of hippocampal cell genesis and mBDNF at different times after treatment in adolescent and adult rats of both sexes
by: Sandra Ledesma-Corvi, et al.
Published: (2023-10-01)

The CXCL12/CXCR4 Axis: An Emerging Therapeutic Target for Chronic Pain
by: Chen Z, et al.
Published: (2025-05-01)

Daily oral intake of theanine prevents the decline of 5-bromo-2′-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress
by: Takeshi Takarada, et al.
Published: (2015-03-01)

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels
by: Graeme Gossel, et al.
Published: (2017-03-01)

Ontogeny of ependymoglial cells lining the third ventricle in mice
by: David Lopez-Rodriguez, et al.
Published: (2023-01-01)

Synthetic Thymidine Analog Labeling without Misconceptions
by: Anna Ivanova, et al.
Published: (2022-06-01)

Identification and Quantification of Proliferating Cells in Skeletal Muscle of Glutamine Supplemented Low- and Normal-Birth-Weight Piglets
by: Elke Albrecht, et al.
Published: (2023-02-01)

Cell cycle synchronization and BrdU incorporation as a tool to study the possible selective elimination of ErbB1 gene in the micronuclei in A549 cells
by: C. Lauand, et al.
Published: (2015-03-01)

Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells
by: Christian Koch, et al.
Published: (2022-12-01)

The role of CXCR3 and its ligands in cancer
by: Xiaoming Wang, et al.
Published: (2022-11-01)

Regional Patterning of Adult Neurogenesis in the Homing Pigeon’s Brain
by: Julia Mehlhorn, et al.
Published: (2022-07-01)

CXCL12 and CXCR4 as Novel Biomarkers in Uric Acid-Induced Inflammation and Patients with Gouty Arthritis
by: Seong-Kyu Kim, et al.
Published: (2023-02-01)

The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration
by: Marco E. Bianchi, et al.
Published: (2020-08-01)

Extracellular Hsp70 Is Involved in the CXCL12/CXCR4 Pathway in Primary Human Nasal Epithelial Cells: A Preliminary Study
by: Seong Hee Kim, et al.
Published: (2023-11-01)

CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
by: Wu Xia, et al.
Published: (2023-08-01)

Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior
by: Maria Sidorova, et al.
Published: (2021-11-01)

The maths of memory
by: Jose Borghans, et al.
Published: (2017-04-01)

Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
by: Joana M.A.C. Gil, et al.
Published: (2005-12-01)

Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations
by: Lingli Wang, et al.
Published: (2025-04-01)

Association of CXCL12 and CXCR4 Genes Polymorphism with Proliferative Diabetic Retinopathy in Diabetic Patients
by: Saba Gharibi, et al.
Published: (2022-10-01)

Correction: Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations
by: Lingli Wang, et al.
Published: (2025-07-01)

Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis
by: I. Aversa, et al.
Published: (2017-08-01)

CXCR4-Targeted Radiopharmaceuticals for the Imaging and Therapy of Malignant Tumors
by: Jingjing Yu, et al.
Published: (2023-06-01)

Involvement of chemokine CXCL12 and its receptor CXCR4 in uterine receptivity and potential relationship to fertility in cattle: a mini review
by: Michael J. D’Occhio, et al.
Published: (2025-08-01)

The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer
by: Raquel Bodoque-Villar, et al.
Published: (2023-09-01)

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment
by: Nathan Reynders, et al.
Published: (2019-06-01)

Time- and Concentration-Dependent Adverse Effects of Paclitaxel on Non-Neuronal Cells in Rat Primary Dorsal Root Ganglia
by: Amira Elfarnawany, et al.
Published: (2023-07-01)

Involvement of CXCR4 in Normal and Abnormal Development
by: Nanako Kawaguchi, et al.
Published: (2019-02-01)

LncRNA MALAT1 silencing represses CXCL12-induced proliferation, invasion, and homing behavior in multiple myeloma by inhibiting CXCR4
by: Jing Ning, et al.
Published: (2024-12-01)

Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia
by: Manoj K. Kashyap, et al.
Published: (2017-05-01)

A semi‐automated observation approach to quantify mouse skeletal muscle differentiation using immunohistochemistry
by: Kenta Shimizu, et al.
Published: (2025-04-01)