Altered SYNJ2BP-mediated mitochondrial-ER contacts in motor neuron disease

Synaptojanin 2 binding protein (SYNJ2BP) is an outer mitochondrial membrane protein with a cytosolic PDZ domain that functions as a cellular signaling hub. Few studies have evaluated its role in disease. Here we use induced pluripotent stem cell (iPSC)-derived motor neurons and post-mortem tissue fr...

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Bibliographic Details
Published in:Neurobiology of Disease
Main Authors: Naemeh Pourshafie, Ester Masati, Amber Lopez, Eric Bunker, Allison Snyder, Nancy A. Edwards, Audrey M. Winkelsas, Kenneth H. Fischbeck, Christopher Grunseich
Format: Article
Language:English
Published: Elsevier 2022-10-01
Subjects:
Spinal and bulbar muscular atrophy
Motor neuron disease
Polyglutamine disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002248

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http://www.sciencedirect.com/science/article/pii/S0969996122002248

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