Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation

Abstract Background Microglia-evoked neuroinflammation contributes to neurodegenerative diseases such as multiple sclerosis (MS). Metabolic reprogramming, including changes in polyunsaturated fatty acids (PUFAs), plays a critical role in MS pathophysiology. Previous studies identified reduced plasma...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Journal of Translational Medicine
المؤلفون الرئيسيون: Xiao-Xi Zhu, Pei-Juan Wang, Shan Chao, Wei-Jia Tang, Long-You Zhao, Li-Mei Yu, Fan Yang
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2025-03-01
الموضوعات:
Ferroptosis
NF-κB signaling
α-dimorphecolic acid
Microglial inflammation
Multiple sclerosis
Metabolomics
الوصول للمادة أونلاين:https://doi.org/10.1186/s12967-025-06296-7

الانترنت

https://doi.org/10.1186/s12967-025-06296-7

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