The Histone Deacetylase Inhibitor I1 Induces Differentiation of Acute Leukemia Cells With MLL Gene Rearrangements via Epigenetic Modification

Acute leukemia (AL) is characterized by excessive proliferation and impaired differentiation of leukemic cells. AL includes acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Previous studies have demonstrated that about 10% of AML and 22% of ALL are mixed lineage leukemia gene rea...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Jingfang Yao, Gentao Li, Zihui Cui, Peilei Chen, Jinhong Wang, Zhenbo Hu, Lei Zhang, Liuya Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Subjects:	acute leukemia mixed lineage leukemia rearranged differentiation therapy HDAC inhibitor epigenetic modification
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.876076/full