A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growthResearch in context

Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases. Through counteracting ubiquitination, deubiquitinases (DUBs) can either positively or negatively regulate UPS...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Xiaofen Li, Qingtian Huang, Huidan Long, Peiquan Zhang, Huabo Su, Jinbao Liu
Format:	Article
Language:	English
Published:	Elsevier 2019-01-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396418305516