Largazole Pharmacokinetics in Rats by LC-MS/MS

A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated. Largazole thiol was extracted with ethyl acetate from human or rat plasma alo...

Full description

Bibliographic Details

Published in:	Marine Drugs
Main Authors:	Mingming Yu, Lilibeth A. Salvador, Sherwin K. B. Sy, Yufei Tang, Ravi S. P. Singh, Qi-Yin Chen, Yanxia Liu, Jiyong Hong, Hartmut Derendorf, Hendrik Luesch
Format:	Article
Language:	English
Published:	MDPI AG 2014-03-01
Subjects:	largazole LC-MS/MS pharmacokinetics protein binding
Online Access:	http://www.mdpi.com/1660-3397/12/3/1623