A degranulation assay using Vγ9Vδ2 T cells for the rapid diagnosis of familial hemophagocytic syndromes

IntroductionHemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder characterized by uncontrolled lymphocyte and macrophage activation and a subsequent cytokine storm. The timely initiation of immunosuppressive treatment is crucial for survival.MethodsHere, we harnessed Vγ9Vδ2...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Olivia Jorisch-Mühlebach, Dina Pitts, Raphaela Tinner, Hong Ying Teh, Conrad Roelli, Seraina Prader, Stefano Vavassori, Jana Pachlopnik Schmid
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	NK cell K562 Vγ9Vδ2 T cell gd T cell HMBPP degranulation assay
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1391967/full