Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL) - multiple rather than a single mechanism.

Despite manifold efforts to achieve reduced-intensity and -toxicity regimens, secondary leukemia has remained the most severe side effect of chemotherapeutic cancer treatment. Rearrangements involving a short telomeric <1kb region of the mixed lineage leukemia (MLL) gene are the most frequently o...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Cell and Developmental Biology
المؤلفون الرئيسيون: Boris eGole, Lisa eWiesmüller
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2015-06-01
الموضوعات:
Apoptosis
replication stress
therapy-related leukemia
MLL breakpoint cluster region
infant acute leukemia
error-prone DNA repair
الوصول للمادة أونلاين:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00041/full

الانترنت

http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00041/full

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