Apelin Does Not Impair Coronary Artery Relaxation Mediated by Nitric Oxide-Induced Activation of BKCa Channels

Apelin-APJ receptor signaling regulates vascular tone in cerebral and peripheral arteries. We recently reported that apelin inhibits BKCa channel function in cerebral arteries, resulting in impaired endothelium-dependent relaxations. In contrast, apelin causes endothelium-dependent relaxation of cor...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Amreen Mughal, Chengwen Sun, Stephen T. O’Rourke
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Subjects:	apelin coronary artery nitric oxide vasorelaxation BKCa channels
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.679005/full