Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration

In humans, new-born infants can regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds great therapeutic potential; however, the molecular pathways that...

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Bibliographic Details

Published in:	eLife
Main Authors:	Elisabetta Gamen, Eleanor L Price, Daniela Pezzolla, Carla De Villiers, Mala Gunadasa-Rohling, Adam B Lokman, Maria-Alexa Cosma, Judith Sayers, Carolina Roque Silva, Rafik Salama, David Robert Mole, Tammie Bishop, Chris W Pugh, Robin P Choudhury, Carolyn A Carr, Joaquim Miguel Vieira, Paul R Riley
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-10-01
Subjects:	heart epicardium hypoxia regeneration
Online Access:	https://elifesciences.org/articles/107419