Deregulation and Targeting of TP53 Pathway in Multiple Myeloma

Multiple Myeloma (MM) is an incurable disease characterized by a clonal evolution across the course of the diseases and multiple lines of treatment. Among genomic drivers of the disease, alterations of the tumor suppressor TP53 are associated with poor outcomes. In physiological situation, once acti...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Katarina K. Jovanović, Guillaume Escure, Jordane Demonchy, Alexandre Willaume, Zoe Van de Wyngaert, Meryem Farhat, Paul Chauvet, Thierry Facon, Bruno Quesnel, Salomon Manier
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-01-01
Subjects:	TP53 multiple myeloma targeted therapy clonal evolution precision medicine
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2018.00665/full