Origin of aromatase inhibitory activity via proteochemometric modeling

Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor candidates with high selectivity, lower...

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Bibliographic Details
Published in:PeerJ
Main Authors: Saw Simeon, Ola Spjuth, Maris Lapins, Sunanta Nabu, Nuttapat Anuwongcharoen, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat
Format: Article
Language:English
Published: PeerJ Inc. 2016-05-01
Subjects:
Aromatase
Quantitative structure–activity relationship
Breast cancer
Data mining
QSAR
Aromatase inhibitor
Online Access:https://peerj.com/articles/1979.pdf

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https://peerj.com/articles/1979.pdf

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