Single cell analysis revealed that two distinct, unique CD4+ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice

Recent advances in research suggest that aging has a controllable chronic inflammatory disease aspect. Aging systemic T cells, which secrete pro-inflammatory factors, affect surrounding somatic cells, and accelerate the aging process through chronic inflammation, have attracted attention as potentia...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yuki Yonemoto, Yasuhiro Nemoto, Ryo Morikawa, Nana Shibayama, Shigeru Oshima, Takashi Nagaishi, Tomohiro Mizutani, Go Ito, Satoru Fujii, Ryuichi Okamoto
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	intraepithelial lymphocyte T cell aging intestinal immunity CD4 T cell scRNAseq
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1340048/full