Co-factor binding confers substrate specificity to xylose reductase from Debaryomyces hansenii.

Binding of substrates into the active site, often through complementarity of shapes and charges, is central to the specificity of an enzyme. In many cases, substrate binding induces conformational changes in the active site, promoting specific interactions between them. In contrast, non-substrates e...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Dipanwita Biswas, Vaibhav Pandya, Appu Kumar Singh, Alok K Mondal, S Kumaran
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3458928?pdf=render