Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities

A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC₅₀ values, with the best compound (<b>10e</b>) being nearly 90 times mor...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Feifei Yang, Na Zhao, Jiali Song, Kongkai Zhu, Cheng-shi Jiang, Peipei Shan, Hua Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2019-07-01
Subjects:	coumarin hydroxamate HDAC inhibitors antitumor growth structure–activity relationship
Online Access:	https://www.mdpi.com/1420-3049/24/14/2569