The Crucial Role of Demannosylating Asparagine-Linked Glycans in ERADicating Misfolded Glycoproteins in the Endoplasmic Reticulum

Most membrane and secreted proteins are glycosylated on certain asparagine (N) residues in the endoplasmic reticulum (ER), which is crucial for their correct folding and function. Protein folding is a fundamentally inefficient and error-prone process that can be easily interfered by genetic mutation...

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Bibliographic Details

Published in:	Frontiers in Plant Science
Main Authors:	Jianjun Zhang, Jiarui Wu, Linchuan Liu, Jianming Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Subjects:	endoplasmic reticulum asparagine-linked glycan endoplasmic reticulum-associated degradation mannosidase protein disulfide isomerases
Online Access:	https://www.frontiersin.org/articles/10.3389/fpls.2020.625033/full