Conventional type 1 dendritic cells in the lymph nodes aggravate neuroinflammation after spinal cord injury by promoting CD8+ T cell expansion

Abstract Background Adaptive immune response is at the core of the mechanism of secondary spinal cord injury (SCI). This study aims to explore the molecular mechanism by which classical dendritic cells (cDC1s) influence CD8+ T cell expansion in SCI. Methods Peripheral blood samples from patients wit...

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Bibliographic Details

Published in:	Molecular Medicine
Main Authors:	Li-Qing Wang, Xiao-Yi Wang, Yue-Hui Ma, Heng-Jun Zhou
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Spinal cord injury Neuroinflammation Conventional type 1 dendritic cells Lymph nodes CD8+ T cell
Online Access:	https://doi.org/10.1186/s10020-024-01059-4