Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Abstract Background Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN, in DS-associated transcriptional regulation and phenotypic modulation....

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Biological Research
المؤلفون الرئيسيون: Zhenglong Guo, Yongchang Zhu, Hai Xiao, Ranran Dai, Wenke Yang, Wei Xue, Xueying Zhang, Bingtao Hao, Shixiu Liao
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2023-12-01
الموضوعات:
Down syndrome
Amniocytes
ATAC-seq and RNA-seq
I-IFN
MX1
AP-1
الوصول للمادة أونلاين:https://doi.org/10.1186/s40659-023-00474-x

الانترنت

https://doi.org/10.1186/s40659-023-00474-x

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