Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Abstract Background Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN, in DS-associated transcriptional regulation and phenotypic modulation....

書誌詳細
出版年:	Biological Research
主要な著者:	Zhenglong Guo, Yongchang Zhu, Hai Xiao, Ranran Dai, Wenke Yang, Wei Xue, Xueying Zhang, Bingtao Hao, Shixiu Liao
フォーマット:	論文
言語:	英語
出版事項:	BMC 2023-12-01
主題:	Down syndrome Amniocytes ATAC-seq and RNA-seq I-IFN MX1 AP-1
オンライン･アクセス:	https://doi.org/10.1186/s40659-023-00474-x

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