Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum

P-glycoprotein (P-gp, ABCB1 member of the ABC (ATP-binding cassette) transporter family) localized in leukemia cell plasma membranes is known to reduce cell sensitivity to a large but well-defined group of chemicals known as P-gp substrates. However, we found previously that P-gp-positive sublines o...

Full description

Bibliographic Details

Published in:	Cells
Main Authors:	Mário Šereš, Lucia Pavlíková, Viera Boháčová, Tomáš Kyca, Ivana Borovská, Boris Lakatoš, Albert Breier, Zdena Sulová
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	multidrug resistance p-glycoprotein tunicamycin-induced ER stress GRP78/BiP CHOP
Online Access:	https://www.mdpi.com/2073-4409/9/4/890