Antitumor effects of immunotherapy combined with BRAF and MEK inhibitors in BRAF V600E metastatic colorectal cancer

Abstract BRAF-mutated colorectal cancer correlates with poor prognosis and limited response to standard treatments. Combining immune checkpoint inhibitors with BRAF/MEK inhibitors shows promise against BRAF-mutant melanoma in both preclinical and clinical trials. Therefore, we hypothesized that the...

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Bibliographic Details

Published in:	Cancer Immunology, Immunotherapy
Main Authors:	Eunyoung Tak, Hye-In An, Amy Sinyoung Lee, Kyuyoung Han, Jiwan Choi, Hyung-don Kim, Yong Sang Hong, Sun Young Kim, Eun Kyung Choi, Jeong Eun Kim, Tae Won Kim
Format:	Article
Language:	English
Published:	Springer 2025-03-01
Subjects:	BRAF V600E BRAF inhibitor MEK inhibitor Anti-PD-L1 Immunotherapy
Online Access:	https://doi.org/10.1007/s00262-025-04005-3