Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation

Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of innate immune responses, but improper and excessive activation can cause inflammatory disease. We previously showed that glycolysis, a metabolic pathway that converts glucose into pyruvate, is essential for NLR...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Hsin-Chung Lin, Yu-Jen Chen, Yau-Huei Wei, Hsin-An Lin, Chien-Chou Chen, Tze-Fan Liu, Yi-Lin Hsieh, Kuo-Yang Huang, Kuan-Hung Lin, Hsueh-Hsiao Wang, Lih-Chyang Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Subjects:	glycolysis lactic acid fermentation pyruvate oxidation NLRP3 inflammasome inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.630380/full