A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers

Abstract Background The APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and is associated with increased risk of amyloid-related imaging abnormalities (ARIA) during anti-amyloid therapy. Accurate identification of ε4 carriers, particularly APOE ε4/ε4 indiv...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Andrés Rodríguez, Olga Calero, Sergio Veiga, Miriam Menacho-Román, Ignacio Arribas, Lluís Cano, Guillermo García-Ribas, Miguel Calero
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Apolipoprotein E4 (ApoE4) Alzheimer's disease (AD) Biochemical assay Plasma biomarkers Non-genetic test Amyloid-related imaging abnormalities (ARIA)
Online Access:	https://doi.org/10.1186/s13195-025-01811-w