Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation

Summary: Mitochondrial ribosomes (mitoribosomes) have undergone substantial evolutionary structural remodeling accompanied by loss of ribosomal RNA, while acquiring unique protein subunits located on the periphery. We generated CRISPR-mediated knockouts of all 14 unique (mitochondria-specific/supern...

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Bibliographic Details

Published in:	iScience
Main Authors:	Taru Hilander, Ryan Awadhpersad, Geoffray Monteuuis, Krystyna L. Broda, Max Pohjanpelto, Elizabeth Pyman, Sachin Kumar Singh, Tuula A. Nyman, Isabelle Crevel, Robert W. Taylor, Ann Saada, Diego Balboa, Brendan J. Battersby, Christopher B. Jackson, Christopher J. Carroll
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Subjects:	biological sciences biochemistry molecular biology cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S258900422401410X