Mechanisms of antigen-dependent resistance to chimeric antigen receptor (CAR)-T cell therapies

Abstract Cancer immunotherapy has reshaped the landscape of cancer treatment over the past decades. Genetic manipulation of T cells to express synthetic receptors, known as chimeric antigen receptors (CAR), has led to the creation of tremendous commercial and therapeutic success for the treatment of...

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Bibliographic Details
Published in:Cancer Cell International
Main Authors: Fatemeh Nasiri, Pouya Safarzadeh Kozani, Faeze Salem, Maral Mahboubi Kancha, Setareh Dashti Shokoohi, Pooria Safarzadeh Kozani
Format: Article
Language:English
Published: BMC 2025-02-01
Subjects:
Chimeric antigen receptor
Resistance
Antigen loss
Antigen downregulation
Solid tumors
Toxicity
Online Access:https://doi.org/10.1186/s12935-025-03697-y

Internet

https://doi.org/10.1186/s12935-025-03697-y

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