LC-MS based sphingolipidomic study on A549 human lung adenocarcinoma cell line and its taxol-resistant strain

Abstract Background Resistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a critical problem in clinics. Sphingolipid (SPL) controls various aspects...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Hao Huang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Jia-Ning Mi, Jing-Rong Wang, Zhi-Hong Jiang
Format:	Article
Language:	English
Published:	BMC 2018-08-01
Subjects:	A549 human lung adenocarcinoma cell line - Taxol-resistant - LC-MS - Sphingolipids - Ceramide
Online Access:	http://link.springer.com/article/10.1186/s12885-018-4714-x