The farnesoid X receptor (FXR) antagonist 7β-isopropylchenodeoxycholic acid improves glucose metabolism in mice on a Western diet

The significant roles of the farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) in regulating metabolic pathways have recently been demonstrated. However, the precise effects of FXR inhibitors on glucose metabolism remain to be elucidated. In this study, we examined the impact...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Alzbeta Stefela, Klara Dohnalova, Hana Lastuvkova, Josef Skoda, Maria Bajnokova, Sophie Lestavel, Veronique Touche, Miroslav Kaspar, Eva Kudova, Milos Hroch, Stanislav Micuda, Otto Kucera, Petr Pavek
Format:	Article
Language:	English
Published:	Elsevier 2025-11-01
Subjects:	Farnesoid X receptor antagonist TGR5 Glucagon-like peptide 1 Glucose transporters
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661825003755